Author: Brian Cusack

The Antibacterial Discovery Nobody Talked About: How Thailand Proved Cannabinoids Kill Superbugs

November 3, 2025 No Comments

Last night, I told you about a discovery in Brazil that surprised the scientific community. Researchers found CBD—cannabidiol—in a common South American shrub called Trema micrantha. A plant that isn’t cannabis. A plant that grows wild across Brazil like a weed. The discovery made headlines. Legal alternatives to cannabis. New CBD sources for countries with restrictive regulations. A botanical workaround for hemp prohibition. Exciting stuff, especially for the convergent evolution angle—nature making the same compound in completely unrelated plant species, separated by millions of years. But while everyone was focused on Brazil’s preliminary findings, a more significant study sat quietly in a peer-reviewed journal, published two years earlier. Thailand. 2021. Same plant genus. Same cannabinoids. But the Thai researchers didn’t stop at chemical analysis. They tested the extracts against multidrug-resistant bacteria. And they worked. This is the story nobody talked about. The Thailand Study: What They Actually Did A team of researchers from multiple Thai universities—Thammasat University, Pibulsongkram Rajabhat University, and Silpakorn University—collaborated on a comprehensive study of Trema orientalis. Same genus as the Brazilian discovery. Different species. Closely related to cannabis through phylogenetic analysis. Trema orientalis grows throughout tropical Asia. Common pioneer species—one of the first plants to colonize disturbed soil. Shows up uninvited in agricultural areas, forest edges, and beach forests. The researchers collected nine specimens from three distinct floristic regions in Thailand: Northern Thailand: Agricultural areas and forest edges in Uttaradit, Phitsanulok, and Phetchabun provinces. Southeastern Thailand: Beach forests in Chanthaburi, Rayong, and Trat provinces along the coast. Southern (Peninsular) Thailand: Agricultural and disturbed areas in Chumphon, Nakhon Si Thammarat, and Songkhla provinces. They specifically collected mature inflorescences—the flowers—during the flowering period from November 2019 to February 2020. Why flowers? Because in the cannabis family (Cannabaceae), cannabinoids concentrate in the flower structures, particularly in trichomes on the surface. The methodology was rigorous. Air-dried without sunlight. Ground into powder. Macerated in methanol for 10 days. Extracted and partitioned into hydrophilic and lipophilic fractions. The lipophilic fraction was further separated using column chromatography with gradient elution. Then analyzed with gas chromatography-mass spectrometry (GC-MS) using internal cannabinoid standards for precise identification. This wasn’t casual exploration. This was systematic, reproducible, scientifically rigorous analysis. Published in PeerJ, a respected peer-reviewed journal, in May 2021. And here’s what they found. The Cannabinoid Profile: CBN Takes the Lead All nine specimens, across all three regions, contained cannabinoids. THC (tetrahydrocannabinol), CBD (cannabidiol), and CBN (cannabinol) appeared in varying concentrations depending on geographic location and growing conditions. But one cannabinoid dominated: CBN. Northern Thailand samples: CBN: up to 357.46 mg/kg THC: up to 89.96 mg/kg CBD: not detected Southeastern Thailand samples (coastal): CBN: 50-55 mg/kg THC: not detected CBD: not detected Southern Thailand samples: CBN: up to 140.19 mg/kg THC: up to 38.13 mg/kg CBD: up to 5.22 mg/kg This is unusual. In cannabis, CBN is typically a minor cannabinoid. It forms when THC degrades through oxidation or aging. You find elevated CBN in old cannabis, stored products, material exposed to light and air. But in Trema orientalis, CBN appears to be the primary cannabinoid the plant actively produces. Not a degradation product. A deliberate biosynthetic output. Why would the plant prioritize CBN over CBD or THC? The answer became clear when they tested antibacterial activity. Testing Against Superbugs: The Part Everyone Missed The Thai researchers obtained four bacterial strains from the Department of Medical Science, Ministry of Public Health, Thailand. Not random bacteria. WHO priority pathogens—the multidrug-resistant superbugs that cause serious infections and resist standard antibiotics: Staphylococcus aureus ATCC 43300: Methicillin-resistant (MRSA). One of the most notorious hospital-acquired infection agents. Causes skin infections, pneumonia, bloodstream infections, and surgical site infections. Resistant to beta-lactam antibiotics including methicillin, oxacillin, and amoxicillin. Staphylococcus aureus ATCC 25923: Standard strain for comparison. Pseudomonas aeruginosa ATCC 27853: Gram-negative bacteria that causes pneumonia, particularly in hospital settings and immunocompromised patients. Produces AmpC β-lactamase—an enzyme that breaks down antibiotics. Naturally resistant to many drug classes. Acinetobacter baumannii ATCC 19606: Notorious for hospital-acquired infections. Causes pneumonia, bloodstream infections, wound infections, and meningitis. Extremely drug-resistant strains have emerged globally. Major problem in intensive care units. These are the bacteria that make infectious disease doctors nervous. The ones developing resistance faster than we develop new antibiotics. The researchers took the cannabinoid-containing fraction (labeled S3 in their study) and tested it using two methods: Disk diffusion assay: Paper disks soaked in extract, placed on bacterial cultures. If the extract inhibits growth, a clear zone appears around the disk. Broth microdilution assay: Serial dilutions to determine the minimum inhibitory concentration (MIC)—the lowest concentration that stops bacterial growth. Both tests followed Clinical and Laboratory Standards Institute (CLSI) guidelines—the gold standard for antimicrobial susceptibility testing. The results: The cannabinoid fraction inhibited all four bacterial strains. Clear zones of inhibition: 8 to 14 millimeters diameter. MIC values: S. aureus ATCC 43300 (MRSA): 64.25 µg/mL S. aureus ATCC 25923: 31.25 µg/mL P. aeruginosa ATCC 27853: 31.25 µg/mL A. baumannii ATCC 19606: 31.25 µg/mL For context, those concentrations are comparable to pharmaceutical antibiotics tested in the same study. The northern Thailand samples—highest in CBN content—showed the strongest antibacterial activity across all bacterial strains. Cannabinoids from Trema orientalis killed multidrug-resistant bacteria at clinically relevant concentrations. And nobody talked about it. Traditional Medicine: Validation Centuries in the Making Here’s where the story gets interesting. Trema orientalis has been used in traditional medicine throughout tropical Asia for centuries. Particularly in Thailand and surrounding regions. The uses are well-documented in ethnobotanical literature: Respiratory infections: Bronchitis, pneumonia, pleurisy—inflammation of the membrane surrounding the lungs. Fever reduction: General antipyretic properties. Infectious diseases: Bacterial and viral infections, particularly of the respiratory system. The traditional preparation method: crush the inflorescences (flowers), extract the liquid, administer to patients—especially children—suffering from lung infections. J.M. Watt and M.G. Breyer-Brandwijk documented this use in their 1962 reference work The Medicinal and Poisonous Plants of Southern and Eastern Africa. Traditional healers across the region used Trema species specifically for respiratory ailments involving infection. Nobody understood the mechanism. The chemistry was unknown. The active compounds were

Nature Made CBD Twice: The Brazilian Plant Discovery That Changes How We Think About Cannabidiol

November 2, 2025 No Comments

Scientists in Brazil just discovered something that changes how we should think about CBD. They found it in a plant that isn’t cannabis. Trema micrantha blume. A common shrub that grows all over South America. Often considered a weed—the kind that sprouts up in abandoned lots and forest edges without anyone planting it. Chemical analysis confirmed it: the plant produces CBD in its fruits and flowers. No THC. Just CBD. The Brazilian government was impressed enough to hand the research team a $104,000 grant to figure out how to extract it and test whether it works as well as cannabis-derived CBD. For countries where cannabis remains illegal, this could be a regulatory game-changer. A legal source of CBD without any of the complications that come with growing Cannabis sativa. But that’s not what caught my attention. What caught my attention is this: Nature made CBD at least twice. Two completely unrelated plants, separated by millions of years of evolution, both produce the exact same molecule. That’s not a coincidence. This article explores what this discovery reveals about CBD itself—why evolution would create the same compound in different plant families, what that tells us about CBD’s biological importance, and whether Brazilian shrubs will actually replace hemp as our CBD source. Spoiler: probably not. But the reasons why are more interesting than you’d think. What They Found (And What They Didn’t) Let’s start with the facts. Who found it: Rodrigo Moura Neto, a molecular biologist at the Federal University of Rio de Janeiro. What they found: CBD in measurable quantities in the fruits and flowers of Trema micrantha blume. What they didn’t find: THC. Not a trace. This matters because cannabis prohibition is largely driven by THC—the psychoactive compound that gets users high. CBD doesn’t do that. It’s non-intoxicating, which is why it’s legal in many places where THC isn’t. But most CBD today comes from hemp, which is technically cannabis with less than 0.2% THC (in the EU) or 0.3% (in the US). Still cannabis. Still subject to regulations, stigma, and in some countries, outright bans. Trema micrantha sidesteps all of that. It’s not cannabis. It’s not even in the same plant family. The Plant Itself Trema micrantha grows throughout Brazil and much of South America. It’s a pioneer species—one of the first plants to colonize disturbed soil. Grows fast, spreads easily, thrives in poor conditions. Farmers and foresters often consider it a weed. An opportunistic shrub that shows up uninvited and takes over cleared land. Which means it’s abundant. Cheap to harvest. Requires no special cultivation. In Brazil, where cannabis remains illegal, this plant could provide a domestic CBD source without breaking any laws. “A legal alternative to using cannabis,” as Moura Neto put it. This Isn’t the First Time Here’s what makes this more than a one-off discovery: scientists had already found CBD in a related plant in Thailand. So we’re not talking about two instances anymore. We’re talking about at least three plant species that produce CBD. A pattern is emerging. CBD production isn’t unique to cannabis. It’s a solution that evolution has discovered multiple times, in multiple locations, in plants that aren’t closely related. What Happens Next The research is still preliminary. Results haven’t been peer-reviewed or published yet. The Brazilian team has a five-year timeline to: Develop optimal extraction methods for Trema Scale up production Test the CBD’s effectiveness in humans Compare it to cannabis-derived CBD Navigate regulatory approval (even non-cannabis CBD needs safety studies) So we’re years away from Trema-derived CBD products hitting shelves. But the discovery itself—the fact that this plant makes CBD at all—tells us something important about the molecule itself. When Nature Invents The Same Thing Twice There’s a term for what happened here: convergent evolution. It’s when unrelated species independently evolve similar traits because they face similar environmental pressures. Evolution finds the same solution multiple times because that solution works. Classic example: flight. Birds evolved wings. So did bats. So did insects. Completely different structures. Bird wings are modified forelimbs covered in feathers. Bat wings are modified hands with skin stretched between elongated fingers. Insect wings are entirely different—chitinous extensions that don’t correspond to any limb structure in vertebrates. Yet all three enable powered flight. Why? Because flight offers massive survival advantages. Access to food sources competitors can’t reach. Escape from predators. Efficient long-distance travel. The advantages are so significant that natural selection favored flying in three completely separate lineages. Eyes: Another Example Camera-like eyes evolved independently at least 50 times in different animal groups. Octopus eyes look remarkably similar to human eyes—lens, iris, retina, the whole setup. But they developed through completely different evolutionary pathways. Our retinas are “backwards” (light-sensing cells face away from incoming light). Octopus retinas are “forwards” (more efficient design, actually). Yet both converged on the same basic structure because it’s really effective at capturing visual information. Echolocation Bats and dolphins both use biological sonar to navigate and hunt. Bats evolved it to hunt flying insects in darkness. Dolphins evolved it to navigate murky ocean waters and detect prey. Same solution. Different environments. Different evolutionary histories. What This Tells Us When the same trait evolves multiple times independently, it’s solving a real problem. The solution is effective enough that natural selection keeps discovering it. These aren’t lucky accidents. They’re optimized solutions to specific challenges. Now apply this to CBD. Cannabis and Trema micrantha are unrelated plants. Different families. Different evolutionary paths. Millions of years of separation. Yet both produce cannabidiol. The question: What problem is CBD solving that two completely different plant species would independently evolve to produce it? The Plant’s Perspective: What’s CBD For? We tend to think about CBD in terms of what it does for humans. Pain relief. Anxiety reduction. Sleep support. But plants didn’t evolve CBD for us. They evolved it for themselves. Protection Against UV Radiation CBD and other cannabinoids absorb ultraviolet light. This protects plant tissues—especially flowers and developing seeds—from UV radiation damage. Think of it as botanical sunscreen. Cannabis

Lion’s Mane for Cognitive Function: The Complete Study Breakdown

October 21, 2025 No Comments

If you’re reading this, you either replied to our email about Lion’s Mane and memory, or you’re one of the people considering joining our community replication study. Either way, you deserve to know exactly what the science says. Not marketing spin. Not cherry-picked data. The full picture. This breakdown covers the two most important Lion’s Mane studies for cognitive function: Let’s start with the study that changed everything. Study #1: The Mori Study (2009) Full Citation Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. “Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial.” Phytother Res. 2009 Mar;23(3):367-72. Read the full study here → Why This Study Matters Before 2009, Lion’s Mane (Hericium erinaceus, also called Yamabushitake in Japan) was primarily studied for: But there was no human data showing it could actually improve cognitive function in people with memory concerns. The Mori study changed that. It’s the first (and for a long time, the only) double-blind, placebo-controlled clinical trial testing Lion’s Mane specifically for cognitive impairment in older adults. This is the study that every reputable Lion’s Mane supplement company cites when they talk about “clinically studied for brain health.” The question is: Does what’s in their bottle match what was in this study? More on that later. Study Design: What They Actually Did Population: What is MCI? It’s the stage between normal age-related memory decline and dementia. People with MCI notice memory problems, others might notice too, but it’s not severe enough to interfere significantly with daily life. About 10-20% of people over 65 have MCI, and it often (but not always) progresses to dementia. Intervention: Source Material: The tablets contained dried powder of Lion’s Mane fruiting bodies (the actual mushroom, not mycelium grown on grain). The mushroom was cultivated in Japan specifically for this study. Key Detail: This was a double-blind study, meaning neither the participants nor the researchers knew who was getting Lion’s Mane vs. placebo until after the data was analyzed. This is the gold standard for eliminating bias. How They Measured Cognitive Function The researchers didn’t just ask people “do you feel smarter?” They used a validated assessment tool called the HDSR (Hasegawa Dementia Scale-Revised) which is widely used in Japan to assess cognitive function. The HDSR tests: Scores range from 0-30. Lower scores indicate greater cognitive impairment. Participants were tested at: The Results: What Actually Happened Here’s where it gets interesting. At baseline (week 0): During treatment (weeks 8-16): The Lion’s Mane group showed progressive improvement in cognitive scores throughout the 16 weeks: The placebo group? Their scores stayed essentially the same or declined slightly (which is expected with MCI). Statistical significance: The difference between groups was significant at week 12 (p<0.05) and highly significant at week 16 (p<0.01). In plain English: This wasn’t chance. This was a real, measurable improvement. After stopping (week 20): This is the part most supplement companies don’t mention. Four weeks after participants stopped taking Lion’s Mane, their cognitive scores declined back toward baseline. They didn’t drop all the way back immediately, but the trajectory was clear: the benefits required ongoing supplementation. What Does This Actually Mean? Let’s be honest about what this study shows and what it doesn’t. What it DOES show: What it DOESN’T show: Clinical significance: A 4-point improvement on the HDSR (which is roughly what the Lion’s Mane group achieved) might sound small, but in the context of MCI, it’s substantial. For reference: Safety and Tolerability This is important: No adverse events were reported in the Lion’s Mane group. No stomach issues. No headaches. No interactions. No participants dropped out due to side effects. Compare this to pharmaceutical cognitive enhancers, which often cause: Lion’s Mane appears to be remarkably well-tolerated, even at 3g daily for 16 weeks. Study Limitations (Being Honest) No study is perfect. Here are the limitations: The Study-Washing Problem Here’s why this study matters for choosing a Lion’s Mane supplement: What the study used: What most supplements provide: To match the Mori study, you would need to take: This is why people try Lion’s Mane and feel nothing. They’re not taking what the study used. Study #2: The Mechanism (Martínez-Mármol et al., 2023) Full Citation Martínez-Mármol R, Chai Y, Conroy JN, et al. “Hericerin derivatives activates a pan-neurotrophic pathway in central hippocampal neurons converging to ERK1/2 signaling enhancing spatial memory.” J Neurochem. 2023;165(6):791-808. Read the full study here → Why This Study Matters The Mori study proved that Lion’s Mane works. The Martínez-Mármol study figured out how. This 2023 study from the University of Queensland (Australia) is groundbreaking because it: In other words: This isn’t folk medicine anymore. This is molecular neuroscience. What They Discovered The Active Compounds: The researchers isolated and identified specific molecules from Lion’s Mane: These are aromatic compounds with prenyl side chains — basically, small fat-soluble molecules that can cross the blood-brain barrier. The Mechanism: These compounds promote neurite outgrowth (the growth of new neuron branches) and neuritogenesis (the formation of new neural connections) through activation of the ERK1/2 signaling pathway. Here’s what that means in plain English: Your brain has signaling pathways that tell neurons to grow, connect, and strengthen their connections. One of the most important is the ERK1/2 pathway, which leads to: The novel finding: Hericene A activates ERK1/2 through a TrkB-independent pathway. Most neurotrophic compounds (like BDNF, brain-derived neurotrophic factor) work by activating the TrkB receptor. Hericene A doesn’t. It uses a completely different route to arrive at the same destination (ERK1/2 activation). This means Lion’s Mane can potentially work synergistically with other neurotrophic factors, rather than competing for the same receptor. The Animal Study Results They tested Lion’s Mane extracts in mice for 31 days: Doses tested: Results: The most remarkable finding: Purified hericene A at just 5mg/kg was equally potent as 250mg/kg of crude extract. That’s a 50-fold concentration advantage. Why This Matters for Humans Translating mouse doses to human doses isn’t straightforward, but researchers often use a conversion factor of

How CBD Transformed My Public Speaking (Complete Study Breakdown)

September 22, 2025 No Comments

How a 2011 scientific study predicted my real-world experience pitching to judges for nine months straight The room was silent except for the scratch of pens on paper. Three judges sat across from me, their faces unreadable as I wrapped up my latest pitch for Enterprise Ireland’s New Frontiers program. Nine months of these sessions. Nine months of explaining why Suppgenie deserved funding for our AI-powered supplement research engine. Nine months of discovering something I never expected about CBD and performance anxiety. Last week, when they announced that Suppgenie had won “Best Business Opportunity,” I realized this journey had taught me as much about the science of calm as it had about building a business. The Unexpected Discovery I’ve been in the CBD industry for years. I’ve read countless studies, spoken to hundreds of customers, and formulated products based on scientific research. But until I found myself facing monthly pitch sessions that felt like modern-day Dragon’s Den episodes, I’d never personally tested CBD for performance anxiety. The irony wasn’t lost on me. Here I was, running a company that sold products for stress and anxiety, and I was experiencing classic presentation nerves before every Enterprise Ireland session. That’s when I decided to become my own test case. About an hour before each pitch, I started taking 40mg of our full-spectrum Calm oil. Not a massive dose—well within our normal customer recommendations. Just enough to see if the science I’d been reading about actually translated to real-world pressure situations. The results surprised even me. What Changed (And What Didn’t) The anxiety didn’t disappear entirely. That familiar flutter in the stomach was still there. But something fundamental shifted in how my mind and body handled the stress. Before CBD: After CBD: The key difference wasn’t sedation or disconnection. It was clarity under pressure. The Science That Explains It All Curious about what was happening, I used our new AI research tool to dig into the scientific literature on CBD and public speaking anxiety. That’s when I discovered a landmark 2011 study that seemed to predict exactly what I was experiencing. The Brazilian Study That Changed Everything Published in Neuropsychopharmacology, researchers from the University of São Paulo conducted what remains one of the most cited studies on CBD and social anxiety. The setup was ingenious in its simplicity—and terrifying in its realism. The Participants: The Test: If you’ve ever experienced social anxiety, this scenario probably made your palms sweat just reading it. The Dramatic Results The findings were striking. Participants who received CBD showed: Most remarkably, the CBD group’s anxiety scores dropped so low they became statistically similar to a control group of people with no anxiety disorder at all. The placebo group, meanwhile, showed all the classic signs of social anxiety: elevated stress hormones, negative self-evaluation, and impaired performance. The Dose That Surprises Everyone Here’s where the study gets interesting for practical application. The researchers used 600mg of pure CBD isolate—a massive dose that’s far higher than what anyone needs in daily life. Why so high? Because academic researchers aim for crystal-clear results. They wanted to ensure any effects would be measurable and statistically significant. Think of it as “turning up the volume” on the intervention to see definitive proof of concept. But in my real-world pitching experience, I was using about 40mg of full-spectrum CBD oil—roughly one-fifteenth of the study dose. Why Lower Doses Work in Practice The difference comes down to the type of CBD and the entourage effect: Study Protocol: Real-World Application: It’s like comparing a single trumpet playing at maximum volume versus a full orchestra playing in harmony. The orchestra achieves richer, more nuanced effects at lower individual volumes. The Neuroscience Behind the Calm The study’s brain imaging revealed fascinating insights into how CBD affects anxiety at the neurological level. CBD appears to work on several key brain regions: The Amygdala: Often called the brain’s “alarm system,” this region triggers fight-or-flight responses. CBD helps modulate amygdala hyperactivity, reducing the intensity of threat perception. Hippocampus: Critical for memory formation and emotional processing. CBD supports healthier stress response patterns and prevents excessive rumination. Prefrontal Cortex: The brain’s executive center responsible for decision-making and emotional regulation. CBD enhances connectivity here, improving cognitive control under pressure. 5-HT1A Receptors: These serotonin receptors are key to mood regulation. CBD acts as an agonist at these sites, promoting feelings of calm and well-being. This multi-target approach explains why CBD’s anti-anxiety effects feel different from pharmaceutical interventions. Rather than dampening all emotions or cognitive function, it seems to optimize the brain’s natural stress response systems. From Lab to Real Life: Nine Months of Testing Armed with this scientific understanding, I became more intentional about using CBD for my Enterprise Ireland presentations. Each pitch became both a business opportunity and a personal experiment in applied neuroscience. The Protocol I Developed Timing: 60-90 minutes before each presentation Dose: 40mg of full-spectrum CBD oil Method: Sublingual (under the tongue) for faster absorption Consistency: Same routine for every session What I Learned About Optimal Use Timing Matters: The study showed peak effects 90 minutes post-dose, which aligned perfectly with my experience. Taking CBD too close to presentation time (30 minutes or less) didn’t provide the same benefits. Less Is Often More: Higher doses (75mg+) occasionally made me feel slightly drowsy. The sweet spot seemed to be in the 30-50mg range for acute anxiety management. Preparation Still Counts: CBD enhanced my natural preparation, but it wasn’t magic. I still needed to know my material and practice my delivery. Consistency Builds Confidence: Knowing I had a reliable tool for managing presentation anxiety made me more willing to take on challenging speaking opportunities. The Broader Implications for Performance Anxiety The 2011 study and my personal experience highlight something important about CBD’s role in performance situations. This isn’t about “getting high” or escaping reality—it’s about optimizing your brain’s natural ability to handle pressure. Common Performance Anxiety Triggers That CBD May Help: What CBD Doesn’t Do (Setting Realistic Expectations) It’s important to be honest

Better Than Pills: The Natural Compounds That Inspired Big Pharma

June 17, 2025 No Comments

That Lion’s Mane coffee you’re sipping? It’s closer to real medicine than you think. For decades, we’ve been sold a false binary:Natural = soft. Synthetic = strong. But that’s not how modern medicine works.Pharma doesn’t ignore nature. It studies it. Copies it. Patents it. Aspirin came from willow bark.Morphine from poppies.Quinine for malaria from cinchona trees. Now, it’s happening again—with CBD, THC, Lion’s Mane, and more. These “supplements” are quietly becoming the prototypes for tomorrow’s prescription drugs. This article traces the surprising lineage from plants and fungi to billion-dollar pharmaceutical breakthroughs—and what it means for how you take care of yourself today. Section 1: CBD’s Rise from Controversy to Clinic In 2018, the FDA approved Epidiolex, the world’s first prescription drug derived from CBD. Not a synthetic replica. Real cannabidiol, extracted from the cannabis plant, purified, and formulated to treat severe pediatric epilepsy: Dravet syndrome, Lennox-Gastaut, and tuberous sclerosis complex. The numbers are staggering: $1.6 billion in global revenue in 2023 Projected to reach $17.5 billion by 2031 Roughly 50% of patients experience a 25–50% reduction in seizures (Source: FDA.gov, ScienceDirect, VerifiedMarketResearch) What was once labeled a wellness trend—or dismissed as stoner medicine—is now delivering measurable results for children with debilitating conditions. That’s not hype. That’s hard science. And Epidiolex is just one in a growing family of cannabis-based drugs. Dronabinol (Marinol / Syndros): Pharma’s First THC Clone Approved by the FDA in 1985, Dronabinol was one of the earliest efforts to turn cannabis into medicine. It’s a synthetic version of delta-9-THC, the psychoactive compound in marijuana. Dronabinol is used to: Stimulate appetite in AIDS-related anorexia Relieve nausea and vomiting in chemotherapy patients This wasn’t a hemp oil or a tincture. It was a pill—prescribed, dosed, and regulated. And it paved the way for more advanced cannabinoid medicines. Nabiximols (Sativex): Full-Spectrum Cannabis, Prescribed Then came Sativex, a 1:1 THC:CBD mouth spray derived from real cannabis plants. Approved in the UK in 2010 and used globally for: Multiple sclerosis-related muscle spasticity Neuropathic pain Overactive bladder in neurodegenerative diseases What’s remarkable? Sativex is full-spectrum. It uses the same concept as Dr. Hemp Me’s products: multiple cannabinoids working together, not isolated in a lab. This drug proved what many wellness advocates had long suspected—the entourage effect is real, and pharma knows it. Section 2: The Mushroom Compounds Pharma Can’t Ignore While cannabis has already reached the regulatory finish line, mushrooms are lining up at the starting gate. And the one leading the charge is Lion’s Mane (Hericium erinaceus). For centuries, it was revered in traditional medicine. Today, it’s being studied by neuroscientists for one key reason: It helps your brain grow. Lion’s Mane and Nerve Growth Factor (NGF) Lion’s Mane contains two bioactive families: Hericenones – Found in the fruiting body Erinacines – Found in the mycelium Together, these compounds stimulate Nerve Growth Factor (NGF)—a protein essential for: Brain cell regeneration Repairing damaged neurons Slowing cognitive decline In animal studies, Lion’s Mane improves: Memory Learning capacity Synaptic plasticity In human studies, researchers found: Faster processing speeds in healthy adults Decreased depression and anxiety in elderly patients Better sleep and emotional regulation during menopause (Source: MDPI, PubMed Central, University of Queensland) This isn’t wishful thinking. Neurotech companies are now exploring NGF-targeted drugs using derivatives of Lion’s Mane for Alzheimer’s, Parkinson’s, and post-stroke recovery. It’s only a matter of time before the first “brain drug” built on mushrooms hits the market. Beyond Lion’s Mane: Fungi Under the Microscope Lion’s Mane is just the beginning. Reishi is being studied for immune modulation and blood pressure regulation. Cordyceps is gaining attention for its impact on oxygen utilization and athletic performance. Psilocybin—the compound in psychedelic mushrooms—is undergoing Phase 3 trials for treatment-resistant depression and PTSD. For years, mushrooms were wellness’s quiet ally. Now they’re pharma’s next frontier. Section 3: Why Dr. Hemp Me Isn’t a Wellness Trend At Dr. Hemp Me, we’re not riding waves—we’re building the bridge between wellness and evidence-based practice. Our ethos: Full-spectrum over isolates – Because synergy matters Clinically relevant doses – Not pixie dust Rigorous third-party lab testing – Every batch, every time We design supplements the way pharma designs medicine: for safety, consistency, and real physiological results. It’s not just “clean label.” It’s clean science. Our CBD oils, capsules, gummies, and mushroom blends follow the same formulation principles that pharma now respects—just without the billion-dollar barrier to access. Section 4: How to Use Nature the Smart Way We’ll say it clearly: A supplement is not a substitute for a prescription drug. But it doesn’t need to be in order to work. If you’re: Managing chronic pain Trying to sleep through the night again Looking for natural anxiety support Or seeking cognitive sharpness without side effects …then using supplements with intelligence, precision, and honesty matters more than ever. Dr. Hemp Me makes this easy: Start low, go slow. We guide you. Read the lab results. They’re posted online. Email us your questions. We’re here to educate, not upsell. Because wellness shouldn’t feel like a guessing game. Bonus Section: Other Famous Drugs That Came from Nature Still think supplements can’t lead to real medicine? Here’s a short list of blockbuster drugs that started with plants or fungi: Drug Derived From What It Treats Aspirin Willow Bark Pain & Inflammation Morphine Opium Poppy Severe Pain Metformin French Lilac Type 2 Diabetes Paclitaxel (Taxol) Pacific Yew Tree Ovarian/Breast Cancer Quinine Cinchona Bark Malaria Penicillin Penicillium Mold Bacterial Infections What’s “alternative” today often becomes “essential” tomorrow. Final Word: Nature Is Not an Alternative. It’s the Origin. CBD was once a curiosity—now it’s a regulated anti-seizure drug. Lion’s Mane was once a folk remedy—now it’s entering Alzheimer’s research. And the line between “supplement” and “pharma” is thinner than most people think. So whether you’re drinking adaptogenic tea, taking mushroom capsules, or using CBD oil for stress or sleep… You’re not just following a wellness trend. You’re stepping into the earliest phase of what might one day be medicine. Nature doesn’t wait for headlines. It’s already working.

How Daily CBD May Help Reduce Alcohol Cravings: What a New Clinical Study Reveals

June 5, 2025 No Comments

Alcohol Use Disorder (AUD) is one of the most difficult health challenges to overcome. For many, quitting alcohol isn’t just about stopping a behavior. It’s about calming the inner storm—the stress, the cravings, the anxiety, the trauma that alcohol once numbed. And for decades, treatment options have remained largely the same: counseling, medication, abstinence, willpower. But now, a new player is emerging on the scene—CBD. And it’s not just hype. A peer-reviewed, randomized, placebo-controlled clinical trial published in The American Journal of Psychiatry in 2024 has added real scientific weight behind CBD’s potential as a tool for reducing alcohol cravings and preventing relapse in people with AUD. In this article, we’ll walk through the key findings of this study, why they matter, and how this fits into the bigger picture of CBD research—and your health. What Was the Study? The title of the study is: “Cannabidiol Reduces Alcohol Craving and Prevents Relapse in Individuals With Alcohol Use Disorder.”(Study Link) It was conducted by a team of researchers from multiple clinical and academic institutions, and it followed the highest standard for clinical research:randomized, double-blind, placebo-controlled. Study Design: Participants: 70 adults diagnosed with Alcohol Use Disorder Treatment Duration: 28 days CBD Dose: 800 mg of pharmaceutical-grade oral CBD per day (split into two doses) Control Group: Matching placebo Setting: Inpatient withdrawal program followed by outpatient care The goal?To assess whether CBD could reduce alcohol cravings, delay relapse, and improve outcomes for people with a history of alcohol dependency. Key Results 1. CBD Reduced Alcohol Cravings Significantly One of the most striking findings was that participants in the CBD group reported significantly fewer cravings for alcohol compared to those in the placebo group. This wasn’t a subtle effect—it was clinically meaningful. Cravings are one of the strongest predictors of relapse. If you reduce them, you give someone a fighting chance to stay sober. 2. CBD Improved Cognitive Function During Withdrawal Alcohol withdrawal is not only uncomfortable—it can impair memory, attention, and executive function. The CBD group showed better performance on cognitive tasks, particularly those measuring working memory and attention. That means they were not only resisting cravings—they were thinking more clearly too. This is important because many people in early recovery struggle to make decisions and stay focused. CBD may support mental clarity during this fragile phase. ⏳ 3. CBD Delayed Relapse & Reduced Heavy Drinking Days Those receiving CBD were less likely to relapse and had fewer heavy drinking days during the follow-up period. It didn’t just help in the moment—it changed behavior over time. Why Does This Matter? AUD affects more than 100 million people globally.Relapse rates can be as high as 60–70% within the first year after quitting. We need better tools.We need gentler, more supportive solutions that don’t just numb the cravings, but actually rebalance the nervous system. This is where CBD shines. How Does CBD Help With Alcohol Addiction? CBD is short for cannabidiol, a non-intoxicating compound found in hemp and cannabis plants. It works by interacting with the endocannabinoid system (ECS)—a complex network of receptors involved in mood regulation, inflammation, pain, memory, and reward. Here’s what the research suggests: CBD modulates GABA and glutamate activity, which are both involved in addiction and withdrawal. It reduces anxiety and stress, two major triggers for relapse. It may protect the brain from neuroinflammation and damage caused by alcohol. It reduces impulsivity and helps restore self-control. Put simply:CBD doesn’t “block” cravings—it helps your brain function more calmly and clearly.It quiets the noise.It creates space between impulse and action. How This Compares to Other Treatments There are currently three main FDA-approved medications for AUD: Disulfiram (Antabuse): Causes unpleasant reactions if you drink. Naltrexone: Reduces the rewarding effects of alcohol. Acamprosate: Helps normalize brain function post-alcohol. These medications have their place—but they often come with side effects or adherence issues. CBD offers a non-intoxicating, well-tolerated, and multi-target approach. This study adds to a growing body of evidence suggesting that CBD may eventually be used as a complementary or standalone option for alcohol recovery. What Dose Was Used in the Study? This particular study used 800 mg/day of oral CBD, split into two doses of 400 mg. That’s a pharmaceutical-grade dose, significantly higher than most over-the-counter supplements. However, previous smaller studies have shown benefits even at lower doses—as little as 15–50 mg per day—particularly for stress, anxiety, and general cravings. So while 800 mg is promising in clinical settings, many people may benefit from more accessible, lower daily doses of high-quality, full-spectrum CBD. But Is It Safe? The study reported no significant side effects in the CBD group. Participants tolerated the 800 mg/day dose well, with no liver toxicity, no behavioral impairment, and no adverse events. This matches previous safety data showing that CBD is one of the safest plant compounds ever studied. Section 4: Why This Matters – CBD as a Tool for Recovery What makes these findings so important? Cravings are a major driver of relapse. Finding non-addictive ways to reduce them can change lives. CBD offers a low-risk profile. Compared to some pharmacological options (like naltrexone or disulfiram), CBD appears to carry fewer side effects. This study used real-world dosing. A 15mg daily capsule mirrors what many people already use for general wellness, making it easy to translate into practice. Natural doesn’t mean unscientific. This study validates what many have experienced firsthand—CBD can support emotional regulation, reduce anxiety, and now, potentially reduce addictive cravings. Section 5: How CBD Might Work in the Brain While researchers are still studying the exact mechanisms, there are several theories for how CBD might reduce alcohol cravings: Regulation of the endocannabinoid system: CBD interacts with CB1 and CB2 receptors that help regulate mood, stress, and reward pathways. Modulation of dopamine and serotonin levels: By stabilizing these neurotransmitters, CBD may reduce the compulsive desire for reward-seeking behaviors like alcohol use. Reduction of stress and anxiety: Many people drink to escape anxiety or emotional discomfort. CBD’s well-documented calming effects may help reduce that drive. Improved sleep: Poor

How to Build a Consistent Wellness Routine with Supplements

April 30, 2025 No Comments

When it comes to real, lasting wellness, it’s not about chasing perfection. It’s about what you do daily. Consistency beats intensity every single time. Most people think they need a shelf full of supplements or a complicated health regime to feel better. But the truth is, you need just a few carefully chosen supplements, taken consistently, wrapped into a routine you can stick to for life. Here’s how to build a consistent wellness routine that actually delivers results. 1. Understand Why Consistency Matters More Than Anything Supplements aren’t magic pills. You don’t pop a capsule of magnesium once and expect perfect sleep. You don’t take CBD oil once and expect a lifetime of stress relief. Real results come from consistent use over weeks and months. Why? Think of supplements like watering a plant — not like pouring gasoline on a fire. Daily small actions lead to powerful long-term change. 2. Choose Core Supplements Based on Your Personal Needs You don’t need everything. You need the right things for your goals. Here’s a simple framework: Goal Core Supplement Stack Stress & Calm CBD Calm + Magnesium Sleep CBD Snooze Oil + Reishi Drops Pain & Recovery Nurocalm Duo (CBD + Curcumin) Mental Clarity CBD Calm + Lion’s Mane Immune Support Chaga Extract + Reishi Start with one or two priorities, not five. When in doubt, focus first on: Calm, Sleep, Pain Relief. These are the foundations of wellness. Once these improve, everything else gets easier. 3. Stack Supplements into Existing Daily Habits The easiest way to stay consistent? Attach your supplements to something you already do every day. For example: The fancy name for this is “habit stacking.” It works because you’re not creating a new behavior — you’re simply adding to an existing one. Less friction = more consistency. 4. Set Reminders Until It Becomes Automatic For the first 2–3 weeks, set reminders. After a few weeks, you won’t need the reminders anymore. It will just feel like part of your normal day. 5. Track Your Wins (Even the Small Ones) You might not feel massive changes immediately. That’s okay. Instead, track small shifts: Keep a simple daily note on your phone or journal. Over time, small wins stack up into big transformations. 6. Avoid These Common Pitfalls Here are the traps to watch out for: Skipping doses: Even missing 2–3 days can disrupt the momentum you’re building. Overcomplicating your routine: Stick to 2–3 key products. Don’t overwhelm yourself trying to “biohack” everything at once. Giving up too soon: Supplements like CBD and functional mushrooms need time to build up effects. 4–6 weeks is when major differences start to show up. Chasing “feeling” something: Not every supplement will create an instant buzz. The goal is subtle, lasting change, not fireworks. 7. Build In Flexibility (So You Stick With It Long-Term) Life happens. Travel, late nights, forgotten doses — it’s okay. Instead of quitting, have “minimum standards.” For example: Flexibility keeps you in the game. Rigidity breaks routines. 8. Bonus Tip: Automate Your Refills Running out of your core supplements can break your rhythm fast. One of the biggest reasons we’re launching our subscription service is because of this: We want to make consistency automatic for you. (And yes — you can pause or cancel anytime. No strings.) Final Thoughts Supplements work best when they’re woven into your life, not crammed into it. Start small. Stay consistent. Track small wins. Allow time for real change to happen. You don’t need a perfect biohacking protocol. You need a handful of real, powerful tools you trust — and the habit of showing up for yourself every day. That’s where the magic is.

How to Actually Start CBD (and Get Results)

April 1, 2025 No Comments

CBD can be a game-changer. But only if you take it the right way. After years of working with customers, digging into the science, and building products around real medical studies—not marketing fluff—I’ve noticed something: Most people don’t get results from CBD because they start wrong. Wrong product. Wrong dose. Wrong expectations. So whether you’re brand new to CBD or just feel like it “never really worked for you,” this guide will walk you through how to actually start using CBD in a way that helps you feel the difference. Step 1: Define Your Primary Goal Before anything else, you need to ask: What do I want CBD to help with? Your answer should guide the product you choose. Here’s how I recommend breaking it down: If You’re Dealing with Stress or Anxiety: Start with CBD Calm — our 10% full-spectrum CBD oil. This is the go-to for first-time users and those looking for calm throughout the day. It’s loaded with 1000mg CBD in just 10ml and has earned praise like: “My anxiety is better but the big difference is in my sleep.” – Sofia “Very high standard. Helps me relax with no side effects.” – Patrick “I’m calmer and able to think better, with clarity.” – Niltelane This oil is non-addictive, third-party lab tested, and backed by our 60-day better-than-risk-free guarantee. If Pain or Inflammation is the Issue: Go straight to the Nurocalm Duo — our 30% full-spectrum CBD oil infused with Turmeric Curcumin and Black Pepper, paired with a free CBD cream. This combo targets pain from both inside and out: Use the oil internally (1–2 drops daily) Use the cream on sore joints or muscles “I found the turmeric oil to definitely help more with pain than the standard oil.” – Michael H “The CBD Turmeric Infused Oil is exceptional in anti-inflammatory & pain relief.” – Sharon “Much more movement. Pain and stiffness nearly gone.” – Elaine This is for those who want a safe, effective alternative to painkillers. If Sleep is What You’re After: Go with CBD Snooze Oil. This 10% CBD oil is combined with L-theanine, Chamomile, and Magnesium for true relaxation. We also include free Reishi Mushroom drops in our Sleep Bundle. “Done wonders for my insomnia and anxiety.” – Ana “The quality is good and I trust Dr. Hemp Me to be a reliable source.” – Celia Step 2: Dose Daily, Not Occasionally CBD isn’t a quick-fix like caffeine or painkillers. It works best when taken consistently. Start with a moderate dose: CBD Calm: 3–5 drops twice daily Nurocalm Duo: 1–2 drops per day + cream on affected areas Snooze: 4–6 drops before bed Stick with it for at least 7–10 days. Most people feel the effects within the first few days—better sleep, less tension, reduced pain. Step 3: Track the Subtle Wins CBD works in the background. You might not feel it hit like a painkiller, but give it a few days and you’ll notice: Better mood More energy Fewer interruptions to your sleep Easier mornings “I have no more anxiety attacks… depressive symptoms are manageable… and I sleep through.” – Katja Track changes with a quick log: How did you sleep? How’s your pain level? Did you feel calmer today? Step 4: Stack or Adjust as Needed Here’s how to build your routine: Morning: CBD Calm for focus and anxiety control Evening: CBD Snooze Oil or Reishi for deep sleep Daily (for pain): Nurocalm Duo internally + cream externally For cognitive support: Add Lion’s Mane to Calm or Snooze Small tweaks lead to big improvements over time. Common Mistakes to Avoid Taking CBD once, expecting magic. Not aligning product with goal (e.g., using Calm for pain). Using low-quality, untested oils (many store-bought brands don’t work). Ignoring dosage consistency. Already Tried CBD and Didn’t Feel It? Here’s why: Your dose was too low. You didn’t take it long enough. You chose the wrong product for your issue. That’s where we come in. “I tried 3 other brands before Dr. Hemp Me. This is the only one that worked.” – Gunnar J “Started on 20%, switched to 10%. Can’t tell the difference – both are fantastic.” – Raymond M Need help picking the right product or routine? Just hit reply or email me directly. brian@drhempme.com Why Dr. Hemp Me? We’ve helped over 13,000 customers across Ireland and Europe get better sleep, relief from chronic pain, and calmer minds. 60-Day Better Than Risk-Free Guarantee 3rd Party Lab Testing Next-Day Delivery (Ireland) Formulas based on real medical studies We’re not here to sell fluff. We’re here to get you results. Try CBD the right way—based on science, not marketing. Start Now with the Formula That Fits Your Life: CBD Calm – 10% Oil for Stress & Anxiety CBD Snooze Oil + Free Reishi for Sleep Nurocalm Duo – 30% CBD Oil with Turmeric + Free Cream Consistency is key. Give it 7–10 days. You’ll know.

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The Science Behind Ashwagandha: How This Ancient Adaptogen Supports Stress Relief, Energy, and Overall Well-Being

March 15, 2025 No Comments

For centuries, Ashwagandha has been one of the most revered herbs in Ayurvedic medicine, known for its ability to combat stress, enhance focus, and restore balance. But what does modern science say about Ashwagandha? As researchers continue to study this ancient herb, compelling evidence suggests that Ashwagandha can help regulate cortisol, support cognitive function, improve sleep quality, and even enhance physical endurance. In this article, we will explore the scientific research behind Ashwagandha, how it works within the body, and why it has become one of the most powerful natural adaptogens for managing stress and promoting long-term wellness. What is Ashwagandha? Ashwagandha (Withania somnifera) is a small, evergreen shrub that grows in India, the Middle East, and parts of Africa. It is classified as an adaptogen, which means it helps the body adapt to stress and restore balance in physiological functions. Traditionally used in Ayurvedic medicine, Ashwagandha has been prescribed for thousands of years to: While these benefits have long been recognized in traditional medicine, modern science is now providing concrete evidence to support these claims. 1. Ashwagandha and Cortisol Regulation: A Natural Stress Reliever One of Ashwagandha’s most well-documented benefits is its ability to regulate cortisol levels. What is Cortisol and Why Does It Matter? Cortisol is often called the “stress hormone” because it is released by the adrenal glands in response to stress. While short-term cortisol spikes are helpful in fight-or-flight situations, chronic stress leads to prolonged high cortisol levels, which can cause: Scientific Evidence on Ashwagandha and Cortisol Reduction Several clinical studies have examined Ashwagandha’s effects on cortisol and stress reduction: The takeaway? Ashwagandha has been clinically proven to help regulate cortisol and promote stress resilience. 2. How Ashwagandha Enhances Cognitive Function and Mental Clarity Stress doesn’t just affect the body—it also impacts brain function, memory, and concentration. Chronic stress and high cortisol levels can lead to: Ashwagandha has been studied for its potential neuroprotective effects, meaning it can help support brain function and cognitive performance. Key Findings from Research on Ashwagandha and Brain Function How Does Ashwagandha Support the Brain? If you’re looking to improve memory, focus, and mental clarity, consistent use of Ashwagandha may be a natural and effective option. 3. Ashwagandha and Sleep: How It Supports Restorative Rest Many people turn to Ashwagandha to help with insomnia and restless sleep, and scientific studies support its role in promoting deep, quality sleep. Clinical Studies on Ashwagandha and Sleep Improvement How to Use Ashwagandha for Better Sleep 4. Ashwagandha and Energy Levels: A Natural Alternative to Caffeine While many people associate Ashwagandha with relaxation, it can also help with energy and endurance when taken in the morning. Research on Ashwagandha for Energy and Physical Performance For those looking for a natural energy boost without caffeine, Ashwagandha may provide sustained energy without the jitters or crashes. Final Thoughts: Why Ashwagandha is One of the Most Powerful Natural Adaptogens With clinical studies supporting its stress-relieving, brain-boosting, sleep-enhancing, and energy-regulating properties, Ashwagandha stands out as one of the most versatile and effective adaptogens available today. Whether you are using it for stress relief, cognitive support, improved sleep, or energy balance, taking Ashwagandha consistently can help you achieve long-term health and wellness benefits.

Why Lion’s Mane Works: The Science of Brain Health

March 9, 2025 No Comments

Have you ever wished you could think clearer, remember more, and stay laser-focused all day? If so, you’re not alone. Many of us struggle with brain fog, forgetfulness, and mental fatigue, especially in today’s fast-paced world. But what if there was a natural way to sharpen your focus, support brain health, and even encourage new brain cell growth? That’s where Lion’s Mane Mushroom comes in. This incredible fungus has been used for centuries in Traditional Chinese Medicine for its cognitive-boosting, nerve-regenerating, and brain-protecting properties. But now, modern science is proving just how powerful it really is. Let’s dive into the research-backed benefits of Lion’s Mane and why taking it consistently can transform your mental performance. 1. Lion’s Mane Stimulates Brain Cell Growth One of the biggest reasons Lion’s Mane is so powerful is because it supports neurogenesis—the growth and repair of brain cells. The Science: Research shows that Lion’s Mane stimulates the production of Nerve Growth Factor (NGF), a protein that helps:✅ Repair and regenerate neurons✅ Improve brain plasticity (your brain’s ability to adapt and form new connections)✅ Protect against cognitive decline Study Highlight: A 2013 study published in International Journal of Medicinal Mushrooms found that Lion’s Mane extract significantly increased NGF levels, promoting the growth and survival of nerve cells. This suggests it may help slow brain aging and support memory. 2. Lion’s Mane Improves Memory and Cognitive Function Do you ever walk into a room and forget why you’re there? Or struggle to recall information when you need it most? Lion’s Mane may enhance memory and cognitive function by protecting neurons and strengthening brain pathways. Study Highlight: A 2019 clinical trial published in Phytotherapy Research found that older adults with mild cognitive impairment who took Lion’s Mane daily for 16 weeks showed significant improvements in memory and recognition compared to those who took a placebo. What This Means for You: Whether you’re studying, working on complex projects, or just want to stay sharp, Lion’s Mane may help enhance memory and learning capacity. 3. Lion’s Mane Helps Reduce Brain Fog and Improve Focus Brain fog can make even simple tasks feel impossible. If you’ve been struggling with mental clarity, Lion’s Mane may be the missing piece. How It Works: Lion’s Mane supports brain function by:✅ Increasing acetylcholine, a neurotransmitter responsible for focus and memory✅ Reducing inflammation in the brain, which is linked to brain fog and mental fatigue✅ Enhancing oxygen flow to the brain, improving alertness Study Highlight: A 2020 animal study found that Lion’s Mane extract significantly enhanced focus and problem-solving abilities, suggesting that it may help with attention and cognitive performance in humans. Real-World Impact: Many users report feeling clearer and more mentally sharp within just a few weeks of daily use. 4. Lion’s Mane May Help Protect Against Cognitive Decline Long-term brain health is just as important as short-term mental clarity. Studies suggest Lion’s Mane may help protect against neurodegenerative diseases like Alzheimer’s and Parkinson’s by reducing amyloid plaques, which are linked to cognitive decline. Study Highlight: A 2016 study published in Biomedical Research showed that Lion’s Mane helped reduce symptoms of memory loss and improve cognitive function in mice with Alzheimer’s disease. What This Means for You: While more research is needed, these findings suggest that Lion’s Mane could be a powerful natural tool for maintaining brain health as you age. 5. How to Get the Most Out of Lion’s Mane To experience the full cognitive benefits, consistency is key. Here’s how to use Lion’s Mane for best results: Take it in the morning – Lion’s Mane is best taken in the morning to boost focus and clarity throughout the day.Use sublingually – Our Lion’s Mane Drops are designed for fast absorption. Drop 1-2 pipettes under your tongue, hold for 30-60 seconds, and swallow.☕ Pair it with coffee – Many users report that Lion’s Mane + coffee creates a smooth, focused energy boost without jitters.Be consistent – Studies show that Lion’s Mane works best when taken daily for at least 4-8 weeks. Pro Tip: Try keeping your Lion’s Mane Drops next to your coffee machine as a morning ritual for optimal results. Final Thoughts: Is Lion’s Mane Right for You? If you want to sharpen focus, enhance memory, reduce brain fog, and support long-term brain health, Lion’s Mane is one of the best natural nootropics available today. And the best part? It’s backed by science. Ready to experience the brain-boosting benefits for yourself? Stay consistent, take it daily, and watch your mental clarity improve. Order Your Next Bottle of Lion’s Mane Here REFERENCES Lion’s Mane Stimulates Brain Cell Growth A study published in the International Journal of Medicinal Mushrooms found that Lion’s Mane extract significantly increased Nerve Growth Factor (NGF) levels, promoting the growth and survival of nerve cells. Lion’s Mane Improves Memory and Cognitive Function A 2019 clinical trial published in Phytotherapy Research found that older adults with mild cognitive impairment who took Lion’s Mane daily for 16 weeks showed significant improvements in memory and recognition compared to those who took a placebo. Lion’s Mane May Help Protect Against Cognitive Decline A study published in Biomedical Research showed that Lion’s Mane helped reduce symptoms of memory loss and improve cognitive function in mice with Alzheimer’s disease.

Author: Brian Cusack

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